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原著論文・総説

2024年

1.   Ninomiya K., Ohta K., Kawasaki U., Chiba S., Inoue T., Kuranaga E., Ohashi K., Mizuno K.Calcium influx promotes PLEKHG4B localization to cell-cell junctions and regulates the integrity of junctional actin filaments. Mol. Biol. Cell, 35(2):ar24 (2024) DOI: 10.1091/mbc.E23-05-0154

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2.   Kunitomi A., Chiba S., Higashitani N., Higashitani A., Sato S., Mizuno K., Ohashi K.

Solo regulates the localization and activity of PDZ-RhoGEF for actin cytoskeletal remodeling in response to substrate stiffness. Mol. Biol. Cell, 35(6):ar87 (2024) DOI: 10.1091/mbc.E23-11-0421

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3.   Ohashi K., Kunitomi A., Chiba S., Mizuno K.

Roles of the Dbl family of RhoGEFs in mechanotransduction – a review. Front. Cell Dev. Biol., 12:1485725 (2024) DOI: 10.3389/fcell.2024.1485725

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2021年

1.   Ninomiya K., Ohta K., Yamashita K., Mizuno K., Ohashi K.

PLEKHG4B enables actin cytoskeletal remodeling during epithelial cell-cell junction formation.

J. Cell Sci., 134, jcs249078 (2021) DOI: 10.1242/jcs.249078

 

2020年

1.   Khan L., Sato K., Okuyama S., Kobayashi T., Ohashi K., Hirasaka K., Nikawa T, Takada K., Higashitani A., Abiko K.

Ultra-high-purity iron is a novel and very compatible biomaterial.

J. Mech. Behav. Biomed. Mater., 106, 103744 (2020) 

 

2.   Isozaki Y., Sakai K., Kohiro K., Kagoshima K., Iwamura Y., Sato H., Rindner D., Fujiwara S., Yamashita K., Mizuno K., Ohashi K.

The Rho-guanine nucleotide exchange factor Solo decelerates collective cell migration by modulating the Rho-ROCK pathway and keratin networks.

Mol. Cell Biol., 31: 741-752 (2020) DOI: 10.1091/mbc.E19-07-0357  

 

3.   大橋一正

細胞競合と力覚応答

医学のあゆみ, 274: 525-530 (2020) DOI:10.1111/gtc.12682

 

2019年

1.   Sato D.X., Ishii Y., Nagai T., Ohashi K., Kawata M.

Human-specific mutations in VMAT1 confer functional changes and multi-directional evolution in the regulation of monoamine circuits.

BMC Evol. Biol., 19: 220 (2019) DOI:10.1186/s12862-019-1543-8.

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2.   Fujiwara S., Matsui T.S., Ohashi K., Mizuno K., Deguchi S.

Keratin-binding ability of the N-terminal Solo domain of Solo is critical for its function in cellular mechanotransduction.

Genes Cells, 24: 390-402 (2019) DOI:10.1111/gtc.12682

 

2018年

1.   Nishimura R., Kato K., Fujiwara S., Ohashi K., Mizuno K.

Solo and keratin filaments regulate epithelial tubule morphology.

Cell Struc. Funct., 43: 95-105 (2018) DOI:10.1247/csf.18010 

 

2.   Fujiwara S., Matsui T.S., Ohashi K., Deguchi S., Mizuno K.

Solo, a RhoA-targeting guanine nucleotide exchange factor, is critical for hemidesmosome formation and acinar development in epithelial cells.

PLoS One, 13: e0195124 (2018) DOI:10.1371/journal.pone.0195124

 

2017年

1.   Ohashi K., Fujiwara S., Mizuno K.

Roles of the cytoskeleton, cell adhesion and rho signalling in mechanosensing and mechanotransduction.

J. Biochem. 161: 245-254 (2017) review 

 

2016年

1.   Fujiwara S., Ohashi K., Mashiko T., Kondo H., Mizuno K.

Interplay between Solo and keratin filaments is crucial for mechanical force-induced stress fiber reinforcement.

Mol. Biol. Cell, 27: 954-966 (2016) 

 

2015年

1.   Abiko H., Fujiwara S., Ohashi K., Hiatari R., Mashiko T., Sakamoto N., Sato M., Mizuno K.

Rho-guanine nucleotide exchange factors involved in cyclic stretch-induced reorientation of vascular endothelial cells.

J. Cell Sci. 128: 1683-1695 (2015) 

 

2.   Ohashi K.

Roles of cofilin in development and its mechanisms of regulation.

Develop. Growth Differ. 57: 275-290 (2015)  review

 

2014年

1.   Homma Y., Kanno S., Sasaki K., Nishita M., Yasui A., Asano T., Ohashi K., Mizuno K.

Insulin receptor substrate-4 binds to Slingshot-1 phosphatase and promotes cofilin dephosphorylation.

J. Biol. Chem. 289: 26302-26313 (2014)

 

2.   Ohashi K., Sampei K., Nakagawa M., Uchiumi N., Amanuma T., Aiba S., Oikawa M., Mizuno K.

Damnacanthal, an effective inhibitor of LIM-kinase, inhibits cell migration and invasion.

Mol. Biol. Cell, 25: 828-840 (2014) 

 

3.   Ohashi K. and Mizuno K. （共著、1項目）

A novel pair of split Venus fragments to detect protein–protein interactions by in vitro and in vivo bimolecular fluorescence complementation assays.

Methods in Molecular Biology, 1174: 247-262, Editor: Ivanov AI, Springer, (2014) Book

 

2013年

1.   Hou X., Katahira T., Ohashi K., Mizuno K., Sugiyama S., Nakamura H.

Coactosin accelerates cell dynamism by promoting actin polymerization.

Dev. Biol., 379: 53-63 (2013)

 

2.   Saito A., Miyajima K., Akatsuka J., Kondo H., Mashiko T., Kiuchi T., Ohashi K., Mizuno K.

CaMKIIβ-mediated LIM-kinase activation plays a crucial role in BDNF-induced neuritogenesis.

Genes Cells, 18: 533-543 (2013) 

 

3.   Hayashi A., Hiatari R., Tsuji T., Ohashi K., Mizuno K.

p63RhoGEF-mediated formation of a single polarized lamellipodium is required for chemotactic migration in breast carcinoma cells.

FEBS Lett. 587: 698-705 (2013)

 

2012年

1.   Ikeda M., Chiba S., Ohashi K., Mizuno K.

Furry Protein Promotes Aurora A-mediated Polo-like Kinase 1 Activation.

J. Biol. Chem. 287: 27670-27681 (2012)

 

2.   Shoji K., Ohashi K., Sampei K., Oikawa M., Mizuno K.

Cytochalasin D acts as an inhibitor of the actin-cofilin interaction.

Biochem. Biophys. Res. Commun. 424: 52-57 (2012)

 

3.   Ohashi K., Kiuchi T., Shoji K., Sampei K., Mizuno K.

Visualization of cofilin-actin and Ras-Raf interactions by bimolecular fluorescence complementation assays using a new pair of split Venus fragments.

Biotechniques 52: 45-50 (2012)

 

4.   大橋一正、辻　拓史、水野健作（共著、1項目）

「Wntの細胞内平面極性シグナルによるRhoファミリーの活性化とアクチン細胞骨格制御機構」

生体の科学, 63: 177-182 医学書院 (2012) review

 

2011年

1.   Ohashi K., Fujiwara S., Watanabe T., Kondo H., Kiuchi T., Sato M., Mizuno K.

LIM-kinase has a dual role in regulating lamellipodium extension by decelerating the rate of actin retrograde flow and the rate of actin polymerization.

J. Biol. Chem. 286: 36340-36351 (2011) 

 

2.   Kiuchi T., Nagai T., Ohashi K., Mizuno K.

Measurements of spatiotemporal changes in G-actin concentration reveal its effect on stimulus-induced actin assembly and lamellipodium extension.

J. Cell Biol. 193: 365-380 (2011)

 

3.   Kiuchi T., Nagai T., Ohashi K., Watanabe N., Mizuno K.

Live-cell imaging of G-actin dynamics using sequential FDAP.

BioArchitecture, 1: 240-244 (2011) review

 

2010年

1.   Tsuji T., OhtaY., Kanno Y., Hirose K., Ohashi K., Mizuno K.

Involvement of p114-RhoGEF and Lfc in Wnt-3a- and Dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells.

Mol. Biol. Cell 21: 3590-3600 (2010)

 

2.   Mishima T., Naotsuka M., Horita Y., Sato M., Ohashi K., Mizuno K.

LIM-kinase is critical for the mesenchymal-to-amoeboid cell morphological transition in 3D matrices.

Biochem. Biophys. Res. Commun. 392: 577-581 (2010)

 

2009年以前

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