原著論文・総説

2009年以前

1.   Takemura M., Mishima T., Wang Y., Kasahara J., Fukunaga K., Ohashi K., Mizuno K.

Ca2+/calmodulin-dependent protein kinase IV-mediated LIM-kinase activation is critical for calcium signal-induced neurite outgrowth.

J. Biol. Chem. 284: 28554-28562 (2009)

 

2.   Chiba S., Ikeda M., Katsunuma K., Ohashi K., Mizuno K.

MST2- and Furry-Mediated Activation of NDR1 Kinase Is Critical for Precise Alignment of Mitotic Chromosomes.

Curr. Biol. 19: 675-681 (2009)

 

3.   Kurita S., Watanabe Y., Gunji E., Ohashi K., Mizuno K.

Molecular dissection of the mechanisms of substrate recognition and F-actin-mediated activation of cofilin-phosphatase slingshot-1.

J. Biol. Chem. 283: 32545-32552 (2008)

 

4.   Kato A., Kurita S., Hayashi A., Kaji N., Ohashi K., Mizuno K.

Critical roles of actin-interacting protein 1 in cytokinesis and chemotactic migration of mammalian cells.

Biochem. J. 414: 261-70 (2008)

 

5.   Horita Y., Ohashi K., Mukai M., Inoue M., Mizuno K.

Suppression of the invasive capacity of rat ascites hepatoma cells by knockdown of Slingshot or LIM kinase.

J. Biol. Chem. 283: 6013-6021 (2008)

 

6.   Kurita T., Gunji E., Ohashi K., Mizuno K.

Actin filaments-stabilizing and -bundling activities of cofilin-phosphatase Slingshot-1

Genes Cells 12: 663-676 (2007)

 

7.   Kiuchi T., Ohashi K., Kurita S., Mizuno K.

Cofilin promotes stimulus-induced lamellipodium formation by generating an abundant supply of actin monomers.

J. Cell Biol. 177: 465-476 (2007)

 

8.   Endo M., Ohashi K., Mizuno K.

LIM-kinase and Slingshot are critical for neurite extension.

J. Biol. Chem. 282: 13692-13702 (2007)

 

9.   Iida J., Ishizaki H., Okamoto-Tanaka M., Kawata A., Sumita K., Ohgake S., Sato Y., Yorifuji H., Nukina N., Ohashi K., Mizuno K.,Tsutsumi T., Mizoguchi A., Miyoshi J., Takai Y., Hata Y.

Synaptic scaffolding molecule alpha is a scaffold to mediate N-methyl-D-aspartate receptor-dependent RhoA activation in dendrites.

Mol. Cell Biol. 27: 4388-4405 (2007)

 

10.  Yamamoto M., Nagata-Ohashi K., Ohta Y., Ohashi K., Mizuno K.

Identification of multiple actin-binding sites in cofilin-phosphatase Slingshot-1L.

FEBS Lett. 580: 1789-1794 (2006)

 

11.  Kobayashi M., Nishita M., Mishima T., Ohashi K., Mizuno K.

MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration.

EMBO J., 25: 713-726 (2006)

 

12.  大橋一正、水野健作（共著、1項目）

「アクチン骨格の再構築制御とシグナル伝達」

遺伝子医学MOOK6 「シグナル伝達病を知る」pp. 119-125

菅村和夫編, メディカルドゥ (2006)

 

13.  Nishita M., Tomizawa C., Yamamoto M., Horita Y., Ohashi K., Mizuno K.

Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration.

J. Cell Biol. 171: 349-359 (2005)

 

14.  Tsumura Y., Toshima J., Leeksma O. C., Ohashi K., Mizuno K.

Sprouty-4 negatively regulates cell spreading by inhibiting the kinase activity of testicular protein kinase.

Biochem. J. 10: 627-637 (2005)

 

15.  Fukuda R., Hayashi A., Utsunomiya A., Nukada Y., Fukui R., Itoh K., Tezuka K., Ohashi K., Mizuno K., Sakamoto M., Hamanoue M., Tsuji T.

Alteration of phosphatidylinositol 3-kinase cascade in the multilobulated nuclear formation of adult T cell leukemia/lymphoma (ATLL).

Proc. Natl. Acad. Sci .U. S. A. 102: 15213-15218 (2005)

 

16.  Nagata-Ohashi K., Ohta Y., Goto K., Chiba S., Mori R., Nishita M., Ohashi K., Kousaka K., Iwamatsu A., Niwa R., Uemura T., Mizuno K.

A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodias.

J. Cell Biol. 165: 465-471 (2004)

 

17.  Tomiyoshi G., Horita Y., Nishita M., Ohashi K., Mizuno K.

Caspase-mediated cleavage and activation of LIM-kinase 1 and its role in apoptotic membrane blebbing.

Genes Cells 9: 591-600 (2004)

 

18.  Okamoto N., Nukada Y., Tezuka K., Ohashi K., Mizuno K., Tsuji T.

AILIM/ICOS signaling induces T-cell migration/polarization of memory/effector T-cells.

Int. Immunol. 16: 1515-1522 (2004)

 

19.  Konakahara S., Ohashi K., Mizuno K., Itoh K., Tsuji T.

CD29 integrin- and LIMK1/cofilin-mediated actin reorganization regulates the migration of haematopoietic progenitor cells underneath bone marrow stromal cells.

Genes Cells, 9: 345-358 (2004)

 

20.  大橋一正、水野健作（共著、1項目）

「アクチンの脱重合制御」

細胞骨格・運動がわかる　pp. 45-53

 三木裕明編,羊土社 (2004)

 

21.  Kaji N., Ohashi K., Shuin M., Niwa R., Uemura T., Mizuno K.

Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells.

J. Biol. Chem. 278: 33450-33455 (2003)

 

22.  Ohta Y., Kousaka K., Nagata-Ohashi K., Ohashi K., Muramoto A., Shima Y., Niwa R., Uemura T., Mizuno K.

Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin.

Genes Cells 8: 811-824 (2003)

 

23.  Endo M., Ohashi K., Sasaki Y., Goshima Y., Niwa R, Uemura T., Mizuno K.

Control of Growth Cone Motility and Morphology by LIM-kinase and Slingshot via Phosphorylation and Dephosphorylation of Cofilin.

J. Neurosci. 23: 2527-2537 (2003)

 

24.  Amano T., Kaji N., Ohashi K., Mizuno K.

Mitosis-specific activation of LIM motif-containing protein kinase and roles of cofilin phosphorylation and dephosphorylation in mitosis.

J. Biol. Chem. 277: 22093-22102 (2002)

 

25.  Matsui S., Matsumoto S., Adachi R., Kusui K., Hirayama A., Watanabe H., Ohashi K., Mizuno K., Yamaguchi T., Kasahara T., Suzuki K.

LIM kinase 1 modulates opsonized zymosan-triggered activation of macrophage-like U937 cells. Possible involvement of phosphorylation of cofilin and reorganization of actin cytoskeleton.

J. Biol. Chem. 277: 544-549 (2002)

 

26.  Yanagita M., Arai H., Nakano T., Ohashi K., Mizuno K., Fukatsu A., Doi T., Kita T.

Gas6 induces mesangial cell proliferation via latent transcription factor STAT3.

J. Biol. Chem. 276: 42364-42369 (2001)

 

27.  Wakayama T., Ohashi K., Mizuno K., Iseki S.

Cloning and characterization of a novel mouse immunoglobulin superfamily gene expressed in early spermatogenic cells.

Mol. Reprod. Dev. 60: 158-164 (2001)

 

28.  Aizawa H., Wakatsuki S., Ishii A., Moriyama K., Sasaki Y., Ohashi K., Sekine-Aizawa Y., Sehara-Fujisawa A., Mizuno K., Goshima Y., Yahara I.

Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse.

Nat. Neurosci. 4: 367-373 (2001)

 

29.  Yanagita M., Arai H., Ishii K., Nakano T., Ohashi K., Mizuno K., Varnum B., Fukatsu A., Doi T., Kita T.

Gas6 Regulates Mesangial Cell Proliferation through Axl in Experimental Glomerulonephritis.

Am. J. Pathol. 158: 1423-1432 (2001)

 

30.  Ohashi K., Hosoya T., Takahashi K., Hing H., Mizuno K.

A Drosophila homolog of LIM-kinase phosphorylates cofilin and induces actin cytoskeletal reorganization.

Biochem. Biophys. Res. Commun. 276: 1178-1185 (2000)

 

31.  Bito H., Furuyashiki T., Ishihara H., Shibasaki Y., Ohashi K., Mizuno K., Maekawa M., Ishizaki T., Narumiya S.

A critical role for a Rho-associated kinase p160ROCK in determining axon outgrowth in mammalian CNS neurons.

Neuron 26: 431-441 (2000)

 

32.  Ishimoto Y., Ohashi K., Mizuno K., Nakano T.

Promotion of the uptake of phosphatidylserine liposomes and apoptotic cells by a product of growth arrest-specific gene, gas6.

J. Biochem. 127: 411-417 (2000)

 

33.  Ohashi K., Nagata K., Maekawa M., Ishizaki T., Narumiya S., Mizuno K.

Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop.

J. Biol. Chem., 275: 3577-3582 (2000)

 

34.  Wakayama T., Nagata K., Ohashi K., Mizuno K., Tanii I.,Yoshinaga K., Oh-oka T., Toshimori K.

The expression and cellular localization of the sperm flagellar protein MC31/CE9 in the rat testis: possible post-transcriptional regulation during rat spermiogenesis.

Arch. Histol. Cytol. 63: 33-41 (2000)

 

35.  Yanagita M., Ishii K., Ozaki H., Arai H., Nakano T., Ohashi K., Mizuno K., Kita T., Doi T.

Mechanism of inhibitory effect of warfarin on mesangial cell proliferation.

J. Am. Soc. Nephrol. 10: 2503-2509 (1999)

 

36.  Nagata K., Ohashi K., Yang N., Mizuno K.

The N-terminal LIM domain negatively regulates the kinase activity of LIM-kinase 1.

Biochem. J. 343: 99-105 (1999)

 

37.  Maekawa M., Ishizaki T., Boku S., Watanabe N., Fujita A., Iwamatsu A., Obinata T., Ohashi K., Mizuno K., Narumiya S.

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.

Science 285: 895-898 (1999)

 

38.  大橋一正、水野健作（共著、1項目）

「LIMキナーゼとコフィリンリン酸化」

実験医学増刊「シグナル伝達　総集編」竹縄忠臣編 pp. 82-88

羊土社 (1999)

 

39.  大橋一正, 水野健作（共著、1項目）

Gas6とそのレセプター

日本血栓止血学会誌 9: 462-466 (1998)

 

40.  Yang N.*, Higuchi O.*, Ohashi K.*, Nagata K., Wada A., Kangawa K., Nishida E., Mizuno K.

Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization.

Nature 393: 809-812 (1998) *) Co-first-authors

 

41.  Ikebe C., Ohashi K., Mizuno K.

Identification of testis-specific (Limk2t) and brain-specific (Limk2c) isoforms of mouse LIM-kinase 2 gene transcripts.

Biochem. Biophys. Res. Commun. 246: 307-312 (1998)

 

42.  Otera H., Okumoto K., Tateishi K., Ikoma Y., Matsuda E., Nishimura M., Tsukamoto T., Osumi T., Ohashi K., Higuchi O., Fujiki Y.

Peroxisome targeting signal type 1 (PTS1) receptor is involved in import of both PTS1 and PTS2: studies with PEX5-defective CHO cell mutants.

Mol. Cell. Biol. 18: 388-399 (1998)

 

43.  Ikebe C., Ohashi K., Fujimori T., Bernard O., Noda T., Robertson J. E., Mizuno K.

Mouse LIM-kinase 2 gene: cDNA cloning, genomic organization, and tissue-specific expression of two alternatively initiated transcripts.

Genomics 46: 504-508 (1997)

 

44.  Nakano T., Ishimoto Y., Kishino J., Umeda M., Inoue K., Nagata K., Ohashi K., Mizuno K., Arita H.

Cell adhesion to phosphatidylserine mediated by a product of growth arrest-specific gene 6.

J. Biol. Chem. 272: 29411-29414 (1997)

 

45.  Tanabe K., Nagata K., Ohashi K., Nakano T., Arita H., Mizuno K.

Roles of gamma-carboxylation and a sex hormone-binding globulin-like domain in receptor-binding and in biological activities of Gas6.

FEBS Lett. 408: 306-310 (1997)

 

46.  Nagata K., Ohashi K., Nakano T., Arita H., Zong C., Hanafusa H., Mizuno K.

Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases.

J. Biol. Chem. 271: 30022-30027 (1996)

 

47.  大橋一正 （共著、2項目）

「Sky」, 「AxlとGas6」

実験医学バイオサイエンス用語ライブラリー「発生・神経・分化」pp. 154-157

中村敏一編, 羊土社 (1996)

 

48.  水野健作, 大橋一正（共著、1項目）

受容体型チロシンキナーゼSkyのリガンドはプロテインSか？

細胞工学 15: 222-228, 秀潤社 (1996)

 

49.  Toshima J., Ohashi K., Okano I., Nunoue K., Kishioka M., Kuma K., Miyata T., Hirai M., Baba T., Mizuno K.

Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells.

J. Biol. Chem. 270: 31331-31337 (1995)

 

50.  Okano I., Hiraoka J., Otera H., Nunoue K., Ohashi K., Iwashita S., Hirai M., Mizuno K.

Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs.

J. Biol. Chem. 270: 31321-31330 (1995)

 

51.  Toshima J., Ohashi K., Iwashita S., Mizuno K.

Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase.

Biochem. Biophys. Res. Commun. 209: 656-663 (1995)

 

52.  Nunoue K., Ohashi K., Okano I., Mizuno K.

LIMK-1 and LIMK-2, two members of a LIM motif containing protein kinase family.

Oncogene 11: 701-710 (1995)

 

53.  Ohashi K., Nagata K., Toshima J., Nakano T., Arita H., Tsuda H., Suzuki K., Mizuno K.

Stimulation of Sky receptor tyrosine kinase by the product of growth arrest-specific gene 6.

J. Biol. Chem. 270: 22681-22684 (1995)

 

54.  Ohashi K., Honda S., Ichinomiya N., Nakamura T., Mizuno K.

Molecular cloning and in situ localization in the brain of rat Sky receptor tyrosine kinase.

J Biochem. 117: 1267-1275 (1995)

 

55.  Ohashi K., Toshima J., Tajinda K., Nakamura T., Mizuno K.

Molecular cloning of a chicken lung cDNA encoding a novel protein kinase with N-terminal two LIM/double zinc finger motifs.

J. Biochem. 116: 636-642 (1994)

 

56.  Mizuno K., Okano I., Ohashi K., Nunoue K., Kuma K., Miyata T., Nakamura T.

Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif.

Oncogene 9: 1605-1612 (1994)

 

57.  Ohashi K., MizunoK., Kuma K., Miyata T., Nakamura T.

Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain.

Oncogene 9: 699-705 (1994)